Cfap20 Gene Summary [Mouse]
Involved in flagellated sperm motility. Located in cilium. Is active in axonemal B tubule inner sheath and sperm flagellum. Is expressed in several structures, including alimentary system; blastocyst; hemolymphoid system gland; olfactory epithelium; and retina nuclear layer. Orthologous to human CFAP20 (cilia and flagella associated protein 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cfap20 |
| Official Name | cilia and flagella associated protein 20 [Source:MGI Symbol;Acc:MGI:107428] |
| Ensembl ID | ENSMUSG00000031796 |
| Bio databases IDs | |
| Aliases | cilia and flagella associated protein 20 |
| Synonyms | 2600014O15Rik, BUG22, C16orf80, cilia and flagella associated protein 20, EVORF, fSAP23, GTL3, T10-2A2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cfap20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CFA20 domain
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- basal bodies
- centriole
- axonemes
- spliceosomes
- nucleoplasm
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cfap20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyglutamylation
- cilium morphogenesis
- regulation of cilium beat frequency involved in ciliary motility
- positive regulation of feeding behavior
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- axonemal microtubule
- motile cilium
- extracellular vesicular exosome
- centriole
- cilium basal body
- cilium
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding