Kirrel3 Gene Summary [Mouse]
Predicted to enable cell adhesion molecule binding activity. Involved in hemopoiesis; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Acts upstream of or within glomerulus morphogenesis; inter-male aggressive behavior; and nervous system development. Located in several cellular components, including axon; dendritic shaft; and extracellular region. Is expressed in several structures, including brain; central nervous system ganglion; embryo ectoderm; limb bud; and sensory organ. Orthologous to human KIRREL3 (kirre like nephrin family adhesion molecule 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kirrel3 |
| Official Name | kirre like nephrin family adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:1914953] |
| Ensembl ID | ENSMUSG00000032036 |
| Bio databases IDs | |
| Aliases | kirre like nephrin family adhesion molecule 3 |
| Synonyms | 1500010O20Rik, 2900036G11RIK, KIRRE, kirre like nephrin family adhesion molecule 3, mKIAA1867, MRD4, NEPH2, Nephrin-like 2, PRO4502, SST4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kirrel3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- major depression
- neuroticism
- depressive disorder
- COVID-19
- pervasive developmental disorder
- Alzheimer disease
- dementia
- FOXO1 fusion positive rhabdomyosarcoma
- soft tissue sarcoma cancer
role in cell
- migration
- adhesion
- morphogenesis
- hematopoiesis
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- Plasma Membrane
- synaptic vesicles
- axons
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kirrel3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- synapse assembly
- glomerulus morphogenesis
- hemopoiesis
- neuron projection morphogenesis
- hippocampus development
- homophilic cell adhesion
- inter-male aggressive behavior
- principal sensory nucleus of trigeminal nerve development
Cellular Component
Where in the cell the gene product is active
- dendrite
- cell-cell junction
- dendritic shaft
- synaptic vesicle
- membrane
- extracellular region
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- cell adhesion molecule binding