Cadm1 Gene Summary [Mouse]
Enables PDZ domain binding activity; protein homodimerization activity; and signaling receptor binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and synapse organization. Acts upstream of or within bone development; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; and unidimensional cell growth. Located in several cellular components, including basolateral plasma membrane; dendrite; and synaptic vesicle. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including central nervous system; metanephros; peripheral nervous system; sensory organ; and tooth. Human ortholog(s) of this gene implicated in breast carcinoma and prostate cancer. Orthologous to human CADM1 (cell adhesion molecule 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cadm1 |
| Official Name | cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:1889272] |
| Ensembl ID | ENSMUSG00000032076 |
| Bio databases IDs | |
| Aliases | cell adhesion molecule 1 |
| Synonyms | 2900073G06Rik, 3100001I08Rik, BL2, cell adhesion molecule 1, IGSF4, IGSF4A, NECL2, RA175, RA175A, RA175B, RA175C, RA175N, SgIGSF, ST17, sTSLC-1, SYNCAM, SynCAM1, TSLC-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cadm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- FERM domain binding motif
- immunoglobulin domain
- ectodomain
- cell adhesion molecule binding
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- PDZ-domain binding
- ERM binding domain
- putative band 4.1 homologues' binding motif
- CD19_double_Ig
- cytoplasmic domain
- Immunoglobulin like
- transmembrane domain
- intracellular domain
- protein homodimerization
- cytosolic tail domain
- PDZ binding motif
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- teratozoospermia
- asthenozoospermia
- oligozoospermia
- metabolic syndrome X
- bladder cancer
- celiac disease
- osteosarcoma
- osteosarcomagenesis
- overnutrition
- obesity
role in cell
- binding in
- apoptosis
- expression in
- activation in
- cell viability
- quantity
- size
- growth
- number
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- glutaminergic synapse
- spot-like adhesion site
- line-like adhesion site
- hemidesmosome-like structure
- cell-matrix contacts
- cell surface
- cellular membrane
- Nucleus
- intercellular junctions
- immunological synapses
- cell-cell contacts
- lateral cell surfaces
- apical cell surfaces
- presynaptic membrane
- postsynaptic membrane
- basolateral membrane
- lateral plasma membrane
- nuclear envelope
- residual bodies
- synaptic vesicles
- growth cone
- nerve ending
- internodes
- synapse
- central supramolecular activation cluster
- Schmidt-Lanterman incisures
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cadm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- heterophilic cell-cell adhesion
- cell recognition
- homophilic cell adhesion
- positive regulation of natural killer cell mediated cytotoxicity
- susceptibility to natural killer cell mediated cytotoxicity
- negative regulation of protein phosphorylation
- liver development
- apoptotic process
- cell differentiation
- T cell mediated cytotoxicity
- detection of stimulus
- positive regulation of cytokine production
- activated T cell proliferation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- cell-cell junction
- synapse
- basolateral plasma membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- cell adhesion molecule binding
- PDZ domain binding
- receptor binding