Map1b Gene Summary [Mouse]
Predicted to enable actin binding activity; microtubule binding activity; and phospholipid binding activity. Involved in regulation of postsynapse assembly. Acts upstream of or within several processes, including establishment of monopolar cell polarity; mitochondrion transport along microtubule; and neuron projection development. Located in several cellular components, including neuronal cell body; photoreceptor outer segment; and postsynaptic density. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including central nervous system; genitourinary system; intestine smooth muscle circular layer; nose; and trigeminal nerve. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 83 and periventricular nodular heterotopia. Orthologous to human MAP1B (microtubule associated protein 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map1b |
| Official Name | microtubule-associated protein 1B [Source:MGI Symbol;Acc:MGI:1306778] |
| Ensembl ID | ENSMUSG00000052727 |
| Bio databases IDs | |
| Aliases | microtubule-associated protein 1B |
| Synonyms | A230055D22, DFNA83, FUTSCH, MAP5, Mapb1, microtubule-associated protein 1B, Mtap1b, Mtap-5, PPP1R102, PVNH9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- microtubule binding
- microtubule binding domain
- constant light chain domain
- binding protein
- actin binding
- protein binding
- MAP1A homology domain
- cytoskeletal regulatory protein binding
Pathways
Biological processes and signaling networks where the Map1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- tremor
- Alzheimer disease
- Parkinson disease
- periventricular nodular heterotopia type 9
- congenital fibrosis of extraocular muscles type 1
- autosomal dominant deafness type 83
- attention deficit hyperactivity disorder
- hereditary disorder
- keratocystic odontogenic tumor
role in cell
- apoptosis
- migration
- growth
- quantity
- differentiation
- formation
- loss
- outgrowth
- shrinkage
- elongation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule fractions
- soluble fraction
- glutaminergic synapse
- axon component
- cell surface
- somatodendritic region
- perinuclear region
- postsynaptic region
- filamentous network
- Plasma Membrane
- microtubules
- cytosol
- synaptic vesicles
- growth cone
- neurites
- nodal axolemma
- photoreceptor outer segments
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- dendritic shafts
- axonal shafts
- dendritic branches
- axon branches
- plasma
- lamellipodia
- parallel fiber
- apical processes
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of neuron differentiation
- response to xenobiotic stimulus
- response to mechanical stimulus
- neuron migration
- response to insecticide
- mitochondrion transport along microtubule
- axonogenesis
- cellular response to peptide hormone stimulus
- odontoblast differentiation
- negative regulation of intracellular transport
- positive regulation of microtubule polymerization
- regulation of microtubule depolymerization
- dendrite development
- peripheral nervous system axon regeneration
- establishment of monopolar cell polarity
- neuron projection development
- response to carbohydrate stimulus
- negative regulation of microtubule depolymerization
- positive regulation of axon extension
- developmental maturation
- microtubule cytoskeleton organization
- synapse assembly
- microtubule bundle formation
- axon extension
- cellular response to growth factor stimulus
- response to estradiol stimulus
- induction of synaptic plasticity by chemical substance
- response to vitamin A
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- synapse
- neuronal cell body
- perikaryon
- microtubule associated complex
- plasma membrane
- microtubule
- photoreceptor outer segment
- growth cone
- dendrite
- perinuclear region of cytoplasm
- varicosity
- dendritic spine
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- structural molecule activity
- phospholipid binding
- microtubule binding