Arid2 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Acts upstream of or within embryonic organ development; heart development; and homeostatic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of SWI/SNF complex; brahma complex; and transcription regulator complex. Is expressed in central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6; colorectal cancer; and hepatocellular carcinoma. Orthologous to human ARID2 (AT-rich interaction domain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arid2 |
| Official Name | AT rich interactive domain 2 (ARID, RFX-like) [Source:MGI Symbol;Acc:MGI:1924294] |
| Ensembl ID | ENSMUSG00000033237 |
| Bio databases IDs | |
| Aliases | AT rich interactive domain 2 (ARID, RFX-like) |
| Synonyms | 1700124K17RIK, 4432409D24RIK, AT-rich interaction domain 2, BAF200, CSS6, DKFZ p686G052, p200, SMARCF3, ZIPZAP, zipzap/p200 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arid2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RFX DNA-binding domain
- transcription regulator
- transcription factor binding
- protein binding
- N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
- ARID/BRIGHT DNA binding domain
- DNA binding
- ARID/BRIGHT DNA binding domain family
Pathways
Biological processes and signaling networks where the Arid2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- hepatocellular carcinoma
- Coffin-Siris syndrome type 6
- organismal death
role in cell
- growth
- expression in
- proliferation
- apoptosis
- differentiation
- assembly
- survival
- epithelial-mesenchymal transition
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arid2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- coronary artery morphogenesis
- negative regulation of cell proliferation
- positive regulation of myoblast differentiation
- embryonic organ development
- positive regulation of cell differentiation
- regulation of nucleotide-excision repair
- nucleosome disassembly
- cardiac muscle cell proliferation
- regulation of transcription from RNA polymerase II promoter
- heart morphogenesis
- chromatin remodeling
- positive regulation of T cell differentiation
- homeostatic process
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- negative regulation of cell migration
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- nuclear matrix
- kinetochore
- RSC complex
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding