Fdx1 Gene Summary [Mouse]
Ferrodoxins are iron-sulfur proteins that facilitate monooxygenase reactions catalyzed by P450 enzymes. The protein encoded by this gene is present in the mitochondrial matrix and transfers electrons from ferredoxin reductase to steroidogenic mitochondrial cytochrome P450 proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | Fdx1 |
| Official Name | ferredoxin 1 [Source:MGI Symbol;Acc:MGI:103224] |
| Ensembl ID | ENSMUSG00000032051 |
| Bio databases IDs | |
| Aliases | ferredoxin 1 |
| Synonyms | Adrenodoxin, ADX, FDX, ferredoxin 1, LOH11CR1D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fdx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- electron carrier
- fer2
- binding protein
- cholesterol monooxygenase (side-chain-cleaving)
- enzyme binding
- iron ion binding
- ferredoxin-NADP reductase
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- epithelial cancer
- adrenal cortex carcinoma
- adrenocortical carcinoma
- thyroid carcinoma
- epithelial thyroid cancer
- gastric epithelial cancer
- organismal death
role in cell
- expression in
- cell death
- binding in
- proliferation
- growth
- migration
- invasion by
- response by
- lipoylation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fdx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to cAMP
- cholesterol metabolic process
- electron transport chain
- steroid biosynthetic process
- hormone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- iron ion binding
- electron carrier activity
- 2 iron, 2 sulfur cluster binding