Fshr Gene Summary [Mouse]
Enables follicle-stimulating hormone receptor activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; gonad development; and regulation of signal transduction. Located in cell surface. Is expressed in early conceptus and gonad. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Orthologous to human FSHR (follicle stimulating hormone receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fshr |
| Official Name | follicle stimulating hormone receptor [Source:MGI Symbol;Acc:MGI:95583] |
| Ensembl ID | ENSMUSG00000032937 |
| Bio databases IDs | |
| Aliases | follicle stimulating hormone receptor |
| Synonyms | follicle stimulating hormone receptor, FSHR1, FSHRO, LGR1, ODG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fshr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- intracellular loop
- protein phosphatase 1 regulatory subunit 42
- tyrosine sulfation motif
- ectodomain
- Leucine rich repeat
- follicle stimulating hormone receptor
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Gonadotropin hormone receptor transmembrane region
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
- beta strand or sheet
- leucine-rich repeat
- transmembrane domain
- hinge domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- Leucine rich repeat N-terminal domain
- cytosolic tail domain
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Fshr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amenorrhea
- cancer
- premature ovarian failure
- neoplasia
- epithelial cancer
- epithelial neoplasia
- polycystic ovary syndrome
- female infertility
- anemia
- impaired glucose tolerance
phenotypes
- abnormal startle reflex
- decreased bone mineral content
- decreased grip strength
- decreased lean body mass
- Sertoli cell hypoplasia
- abnormal abdominal fat pad morphology
- abnormal bone mineralization
- abnormal caput epididymis morphology
- abnormal corpus epididymis morphology
- abnormal dentate gyrus morphology
- abnormal endometrial gland morphology
- abnormal enzyme/coenzyme activity
- abnormal epididymis epithelium morphology
- abnormal epididymis morphology
- abnormal estrous cycle
- abnormal estrus
- abnormal female germ cell morphology
- abnormal granulosa cell morphology
- abnormal grip strength
- abnormal lean body mass
- abnormal male germ cell morphology
- abnormal ovarian follicle number
- abnormal ovarian folliculogenesis
- abnormal ovarian secretion
- abnormal ovary morphology
- abnormal ovary physiology
- abnormal seminiferous tubule epithelium morphology
- abnormal seminiferous tubule morphology
- abnormal sperm axoneme morphology
- abnormal sperm flagellum morphology
- abnormal sperm head morphology
- abnormal sperm nucleus morphology
- abnormal sperm physiology
- abnormal spermatid morphology
- abnormal spermatogenesis
- abnormal spermatogonia morphology
- abnormal spermatogonia proliferation
- abnormal spermiogenesis
- abnormal testes secretion
- abnormal testis development
- abnormal testis size
- abnormal thoracic vertebrae morphology
- abnormal thrombosis
- abnormal uterine environment
- abnormal uterus morphology
- abnormal vagina epithelium morphology
- abnormal vagina orifice morphology
- absent corpus luteum
- absent estrous cycle
- absent mature ovarian follicles
- absent oocytes
- absent ovarian follicles
- adenohypophysis hyperplasia
- anemia
- anovulation
- asthenozoospermia
- astrocytosis
- cachexia
- calcinosis
- decreased bone mineral density
- decreased circulating estradiol level
- decreased circulating progesterone level
- decreased circulating testosterone level
- decreased epididymis weight
- decreased femur weight
- decreased litter size
- decreased ovary weight
- decreased primary ovarian follicle number
- decreased seminal vesicle weight
- decreased testis weight
- decreased uterus weight
- decreased vagina weight
- delayed female fertility
- delayed male fertility
- delayed sexual maturation
- detached acrosome
- early reproductive senescence
- early vaginal opening
- enlarged clitoris
- enlarged endometrial glands
- enlarged sperm head
- enlarged spleen
- enlarged uterus
- female infertility
- hippocampal neuron degeneration
- hunched posture
- impaired ovarian folliculogenesis
- increased anxiety-related response
- increased apoptosis
- increased body weight
- increased circulating follicle stimulating hormone level
- increased circulating luteinizing hormone level
- increased circulating testosterone level
- increased follicle recruitment
- increased follicle stimulating hormone level
- increased gonadotroph cell number
- increased luteinizing hormone level
- increased ovarian carcinoma incidence
- increased ovary tumor incidence
- increased pre-B cell number
- increased thigmotaxis
- increased thyrotroph cell number
- increased total fat pad weight
- increased uterus tumor incidence
- increased uterus weight
- kinked sperm flagellum
- kyphosis
- long gestation period
- myometrium hypoplasia
- neonatal lethality complete penetrance
- neurodegeneration
- obese
- oligozoospermia
- oocyte degeneration
- ovary atrophy
- ovary cysts
- ovary hemorrhage
- pallor
- polyovular ovarian follicle
- postnatal lethality incomplete penetrance
- premature aging
- prolonged diestrus
- prolonged estrous cycle
- reduced female fertility
- reduced male fertility
- small caput epididymis
- small epididymis
- small ovary
- small seminal vesicle
- small seminiferous tubules
- small testis
- small uterus
- teratozoospermia
- thin uterus
- uterine hemorrhage
- uterus adenomyosis
- uterus atrophy
- uterus cysts
- vagina atresia
- vagina atrophy
- weight loss
role in cell
- expression in
- apoptosis
- phosphorylation in
- activation in
- production in
- proliferation
- quantity
- colony formation
- maturation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- intracellular space
- membrane surface
- cellular membrane
- endosomes
- basolateral membrane
- basal membrane
- sperm tail
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fshr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female gamete generation
- male gonad development
- G-protein coupled receptor signaling pathway
- spermatogenesis
- female gonad development
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- follicle-stimulating hormone signaling pathway
- hormone-mediated signaling pathway
- cellular response to follicle-stimulating hormone stimulus
- gonad development
- regulation of protein kinase A signaling cascade
- positive regulation of ERK1 and ERK2 cascade
- activation of adenylate cyclase activity
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- follicle-stimulating hormone receptor activity
- G-protein coupled peptide receptor activity
- protein binding