Pdzd3 Gene Summary [Mouse]
Predicted to enable several functions, including guanylate cyclase inhibitor activity; protein-membrane adaptor activity; and ubiquitin-specific protease binding activity. Predicted to be involved in negative regulation of cGMP-mediated signaling and protein localization to plasma membrane. Located in several cellular components, including apical part of cell; brush border; and cytoplasm. Orthologous to human NHERF4 (NHERF family PDZ scaffold protein 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdzd3 |
| Official Name | PDZ domain containing 3 [Source:MGI Symbol;Acc:MGI:2429554] |
| Ensembl ID | ENSMUSG00000032105 |
| Bio databases IDs | |
| Aliases | PDZ domain containing 3 |
| Synonyms | IKEPP, NaPi-Cap2, NHERF family PDZ scaffold protein 4, PDZD3, PDZK2, RGD1559807 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdzd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- ion channel inhibitor
- protease binding
- guanylate cyclase inhibitor
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- apical compartment
- cellular membrane
- intercellular junctions
- cytosol
- apical cell surfaces
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdzd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- water transport
- ion transport
- receptor guanylyl cyclase signaling pathway
- negative regulation of cGMP-mediated signaling
- response to toxin
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- apical part of cell
- brush border
- apical junction complex
- cytosol
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein anchor
- guanylate cyclase inhibitor activity
- ion channel inhibitor activity
- receptor binding