Ice2 Gene Summary [Mouse]
Predicted to be involved in positive regulation of transcription by RNA polymerase III; snRNA transcription by RNA polymerase II; and snRNA transcription by RNA polymerase III. Located in nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human ICE2 (interactor of little elongation complex ELL subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ice2 |
| Official Name | interactor of little elongation complex ELL subunit 2 [Source:MGI Symbol;Acc:MGI:2135947] |
| Ensembl ID | ENSMUSG00000032235 |
| Bio databases IDs | |
| Aliases | interactor of little elongation complex ELL subunit 2 |
| Synonyms | B230343B06Rik, BRCC1, interactor of little elongation complex ELL subunit 2, LOC679306, NARG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ice2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- Cajal bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ice2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snRNA transcription from RNA polymerase II promoter
- snRNA transcription from RNA polymerase III promoter
- positive regulation of transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- histone locus body
- euchromatin
- nuclear body
- transcription elongation factor complex
- Cajal body
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding