Snrpa1 Gene Summary [Mouse]
Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and spermatogenesis. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Is expressed in several structures, including central nervous system; hemolymphoid system; liver; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Snrpa1 |
| Official Name | small nuclear ribonucleoprotein polypeptide A' [Source:MGI Symbol;Acc:MGI:1916231] |
| Ensembl ID | ENSMUSG00000030512 |
| Bio databases IDs | |
| Aliases | small nuclear ribonucleoprotein polypeptide A' |
| Synonyms | 1500015N06Rik, Lea1, small nuclear ribonucleoprotein polypeptide A', U2A', U2snRNP-A' |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snrpa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine-rich repeat
- occurring C-terminal to leucine-rich repeats
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- protein binding
Pathways
Biological processes and signaling networks where the Snrpa1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- lung cancer
- lung carcinoma
- lung carcinoma process
- lung adenocarcinoma
- lung adenocarcinoma formation
- primary antiphospholipid antibody syndrome
- systemic sclerosis
- infection by HIV-1
role in cell
- expression in
- cell viability
- cell death
- migration
- proliferation
- splicing by
- degradation in
- alternative splicing in
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- nucleoli
- nuclear bodies
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snrpa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- spermatogenesis
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- catalytic step 2 spliceosome
- nuclear speck
- U2-type catalytic step 2 spliceosome
- spliceosomal complex
- U2-type spliceosomal complex
- U2-type precatalytic spliceosome
- U2 snRNP
- small nuclear ribonucleoprotein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- U2 snRNA binding