ICE2 Gene Summary [Human]
This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | ICE2 |
| Official Name | interactor of little elongation complex ELL subunit 2 [Source:HGNC Symbol;Acc:HGNC:29885] |
| Ensembl ID | ENSG00000128915 |
| Bio databases IDs | |
| Aliases | interactor of little elongation complex ELL subunit 2, breast cancer cell 1 |
| Synonyms | B230343B06Rik, BRCC1, interactor of little elongation complex ELL subunit 2, LOC679306, NARG2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ICE2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- Cajal bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ICE2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snRNA transcription from RNA polymerase II promoter
- snRNA transcription from RNA polymerase III promoter
- positive regulation of transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- histone locus body
- euchromatin
- nuclear body
- transcription elongation factor complex
- Cajal body
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding