Ankk1 Gene Summary [Mouse]
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Acts upstream of or within regulation of cell cycle process. Located in cell projection; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and skeletal musculature. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; alexithymia; drug dependence (multiple); and mild cognitive impairment. Orthologous to human ANKK1 (ankyrin repeat and kinase domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ankk1 |
| Official Name | ankyrin repeat and kinase domain containing 1 [Source:MGI Symbol;Acc:MGI:3045301] |
| Ensembl ID | ENSMUSG00000032257 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and kinase domain containing 1 |
| Synonyms | 9930020N01, 9930020N01Rik, ankyrin repeat and kinase domain containing 1, LOC684394, LOC690279, PKK2, sgK288 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ankk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Ankyrin repeats (many copies)
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- Ankyrin repeats (3 copies)
- protein binding
- Protein kinase domain
- Ankyrin repeat
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ankk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell cycle process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cell projection
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity