Ankk1 Gene Summary [Rat]
Predicted to enable ATP binding activity and protein kinase activity. Involved in cellular response to retinoic acid. Predicted to be located in cell projection and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; alexithymia; drug dependence (multiple); and mild cognitive impairment. Orthologous to human ANKK1 (ankyrin repeat and kinase domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ankk1 |
| Official Name | ankyrin repeat and kinase domain containing 1 [Source:RGD Symbol;Acc:1305538] |
| Ensembl ID | ENSRNOG00000025037 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and kinase domain containing 1 |
| Synonyms | 9930020N01, 9930020N01Rik, ankyrin repeat and kinase domain containing 1, LOC684394, LOC690279, PKK2, sgK288 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ankk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Ankyrin repeats (many copies)
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- Ankyrin repeats (3 copies)
- protein binding
- Protein kinase domain
- Ankyrin repeat
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ankk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell cycle process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cell projection
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity