Chn2 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in acrosome assembly. Predicted to be located in synapse. Is expressed in several structures, including central nervous system and retina. Orthologous to human CHN2 (chimerin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Chn2 |
| Official Name | chimerin 2 [Source:MGI Symbol;Acc:MGI:1917243] |
| Ensembl ID | ENSMUSG00000004633 |
| Bio databases IDs | |
| Aliases | chimerin 2 |
| Synonyms | 1700026N20RIK, 4930557O16RIK, ARHGAP3, BCH, chimerin 2, CHN2-3, LOC101928168, LOC644086, RHOGAP3, β chimaerin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- phorbol ester receptor
- protein kinase C conserved region 1 (C1 domain) superfamily
- Src homology 2 (SH2) domain
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Pathways
Biological processes and signaling networks where the Chn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic retinopathy
- preeclampsia
- Alzheimer disease
- vascular dementia
- vaginal discharge
- acute myeloid leukemia
- male pattern hair loss
regulates
- ERK1/2
- RAC
- RAC1
role in cell
- migration
- proliferation
- cell cycle progression
- mitogenesis
- remodeling in
- pruning
- remodeling
- contact repulsion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- signal transduction
- regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- GTPase activator activity