Tpm1 Gene Summary [Mouse]
Enables actin filament binding activity. Involved in cardiac muscle contraction; positive regulation of heart rate by epinephrine; and ventricular cardiac muscle tissue morphogenesis. Acts upstream of or within in utero embryonic development. Located in myofibril. Is expressed in several structures, including central nervous system; gut; heart; limb segment; and musculature. Used to study dilated cardiomyopathy 1Y and hypertrophic cardiomyopathy 3. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Orthologous to human TPM1 (tropomyosin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tpm1 |
| Official Name | tropomyosin 1, alpha [Source:MGI Symbol;Acc:MGI:98809] |
| Ensembl ID | ENSMUSG00000032366 |
| Bio databases IDs | |
| Aliases | tropomyosin 1, alpha |
| Synonyms | AI854628, alpha-TM, BI546321, BQ310475, C15ORF13, C76867, CMD1Y, CMH3, HEL-S-265, HTM-alpha, HTM-α, LVNC9, Slow-twitch alpha tropomyosin, Slow-twitch α tropomyosin, Smooth Muscle Alpha TM, Smooth Muscle α TM, TM1, TM2, Tm3, Tma2, Tma5, Tm alpha, Tmpa, TMSA, Tm α, TPM1kappa, TROPOMYOSIN 1, Tropomyosin 1, alpha, Tropomyosin 1, α, Tropomyosin 5b, Tropomyosin Alpha, Tropomyosin α, α-TM, α tropomyosin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tpm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Tropomyosin
- cytoskeletal protein binding
- structural constituent of muscle
- Tropomyosin like
- structural constituent of cytoskeleton
- actin binding
- protein homodimerization
- protein domain specific binding
- protein binding
- identical protein binding
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Tpm1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- colorectal cancer
- dilated cardiomyopathy
- left ventricular noncompaction type 9
- androgenic alopecia
- breast cancer
- arrhythmogenic right ventricular cardiomyopathy
- hypertrophic cardiomyopathy
- primary dilated cardiomyopathy
role in cell
- growth
- migration
- formation
- contractility
- adhesion
- morphology
- quantity
- sliding
- assembly
- disorganization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- cilia
- cell periphery
- perinuclear region
- cellular membrane
- actin cytoskeleton
- Nucleus
- myofilaments
- sarcomere
- cytosol
- membrane ruffles
- plasma membrane projections
- neurites
- myofibrils
- actin stress fibers
- pseudopodia
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tpm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- ventricular cardiac muscle tissue morphogenesis
- positive regulation of ATPase activity
- sarcomere organization
- regulation of heart contraction
- actin filament organization
- positive regulation of heart rate by epinephrine
- positive regulation of cell adhesion
- cardiac muscle contraction
- wound healing
- positive regulation of stress fiber assembly
- ruffle organization
- regulation of muscle contraction
- cellular response to reactive oxygen species
- negative regulation of cell migration
- muscle filament sliding
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- stress fiber
- actin cytoskeleton
- ruffle membrane
- bleb
- cytosol
- actin filament
- muscle thin filament tropomyosin
- sarcomere
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- identical protein binding
- protein binding
- protein homodimerization activity
- structural constituent of muscle
- actin binding
- protein heterodimerization activity
- structural constituent of cytoskeleton
- cytoskeletal protein binding