Cald1 Gene Summary [Mouse]
Predicted to enable actin binding activity and myosin binding activity. Predicted to be involved in actin filament bundle assembly. Predicted to act upstream of or within regulation of smooth muscle contraction. Located in actin cap and membrane. Is expressed in several structures, including arch of aorta; heart; intestine smooth muscle circular layer; oocyte; and retina. Orthologous to human CALD1 (caldesmon 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cald1 |
| Official Name | caldesmon 1 [Source:MGI Symbol;Acc:MGI:88250] |
| Ensembl ID | ENSMUSG00000029761 |
| Bio databases IDs | |
| Aliases | caldesmon 1 |
| Synonyms | 4833423D12Rik, AI195384, AV071549, AW536160, C920027I18RIK, Cald, caldesmon, caldesmon 1, CDM, H-CAD, h-CD, LOC100503943, LOC107986850, NAG22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cald1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calmodulin binding
- actin binding
- tropomyosin binding
- Caldesmon
- protein binding
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- osteosarcoma
- metastasis
- cancer
- breast adenocarcinoma
- breast carcinoma
- autosomal dominant polycystic kidney disease
- umbilical hernia
- Waldenström macroglobulinemia
- COVID-19
role in cell
- expression in
- migration
- quantity
- proliferation
- cell cycle progression
- growth
- binding in
- formation
- morphology
- contraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cytoskeleton
- cilia
- cell periphery
- postsynaptic region
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- actin filaments
- cytosol
- dendritic spines
- thin filaments
- actin stress fibers
- pseudopodia
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cald1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- muscle contraction
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- stress fiber
- actin cytoskeleton
- cytosol
- plasma membrane
- actin cap
- myofibril
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- actin binding
- cadherin binding
- myosin binding
- tropomyosin binding