Rbpms2 Gene Summary [Mouse]
Predicted to enable mRNA binding activity and protein homodimerization activity. Predicted to be involved in several processes, including embryonic digestive tract morphogenesis; negative regulation of BMP signaling pathway; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; genitourinary system; heart; retina; and trigeminal ganglion. Orthologous to human RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbpms2 |
| Official Name | RNA binding protein with multiple splicing 2 [Source:MGI Symbol;Acc:MGI:1919223] |
| Ensembl ID | ENSMUSG00000032387 |
| Bio databases IDs | |
| Aliases | RNA binding protein with multiple splicing 2 |
| Synonyms | 2400008B06Rik, RGD1561222, RNA binding protein, mRNA processing factor 2, RNA binding protein with multiple splicing 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbpms2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- protein homodimerization
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal aortic aneurysm
- epithelial uterine cancer
- cervical cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
role in cell
- differentiation
- alternative splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbpms2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell proliferation
- negative regulation of BMP signaling pathway
- regulation of alternative nuclear mRNA splicing, via spliceosome
- negative regulation of smooth muscle cell differentiation
- embryonic digestive tract morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- mRNA binding