Maged1 Gene Summary [Mouse]
Enables transcription coactivator activity. Involved in positive regulation of branching involved in ureteric bud morphogenesis; regulation of circadian rhythm; and regulation of macromolecule metabolic process. Acts upstream of or within negative regulation of protein localization to nucleus; positive regulation of apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; hair follicle; and nervous system. Orthologous to human MAGED1 (MAGE family member D1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Maged1 |
| Official Name | MAGE family member D1 [Source:MGI Symbol;Acc:MGI:1930187] |
| Ensembl ID | ENSMUSG00000025151 |
| Bio databases IDs | |
| Aliases | MAGE family member D1 |
| Synonyms | 2810433C11Rik, 5430405L04Rik, Dlixin, DLXIN-1, DXBwg1492e, Mage-D, MAGE family member D1, Melanoma antigen family D1, NRAGE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Maged1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA polymerase III domain
- WQxP repeat
- transcription regulator
- MAGE homology domain
- transcription co-activator
- WQxPxx repeat
- JUN kinase
- necdin homology domain
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Maged1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- neurodegeneration
- anhedonia
- motor dysfunction
- Bell palsy
- plasma cell myeloma
- amyotrophic lateral sclerosis
- Turner syndrome
role in cell
- cell death
- phosphorylation in
- apoptosis
- growth
- cell viability
- proliferation
- differentiation
- cell cycle progression
- function
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- chromatin
- perikaryon
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Maged1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of protein localization to nucleus
- positive regulation of branching involved in ureteric bud morphogenesis
- circadian regulation of gene expression
- positive regulation of transcription, DNA-dependent
- negative regulation of epithelial cell proliferation
- regulation of transcription, DNA-dependent
- regulation of apoptotic process
- regulation of circadian rhythm
- protein localization to nucleus
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
- chromatin
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transcription coactivator activity