Ip6k1 Gene Summary [Mouse]
Predicted to enable inositol hexakisphosphate kinase activity. Involved in negative regulation of cold-induced thermogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human IP6K1 (inositol hexakisphosphate kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ip6k1 |
| Official Name | inositol hexaphosphate kinase 1 [Source:MGI Symbol;Acc:MGI:1351633] |
| Ensembl ID | ENSMUSG00000032594 |
| Bio databases IDs | |
| Aliases | inositol hexaphosphate kinase 1 |
| Synonyms | 1200016D08Rik, IHPK1, inositol hexakisphosphate kinase 1, inositol hexaphosphate kinase 1, InsP6, InsP6k1, Itpk6, LOC100506738, PiUS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ip6k1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- diphosphoinositol-pentakisphosphate kinase
- phosphate group acceptor phosphotransferase
- inositol-hexakisphosphate kinase
- alcohol group acceptor phosphotransferase
- Inositol polyphosphate kinase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- insomnia
- azoospermia
- major depression
- growth failure
regulated by
- tetradecanoylphorbol acetate
- Influenza A virus (A/Japan/305/57(H2N2))
- valproic acid
- beta-estradiol
- IP6K1
- lithium
- 18:1 phosphatidic acid
role in cell
- phosphorylation in
- expression in
- cell viability
- cell death
- cell cycle progression
- recovery
- methylation in
- homologous recombination repair in
- localization in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ip6k1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate biosynthetic process
- inositol phosphate metabolic process
- phosphatidylinositol phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- inositol heptakisphosphate kinase activity
- inositol hexakisphosphate kinase activity
- protein binding
- inositol-1,3,4,5,6-pentakisphosphate kinase activity
- inositol diphosphate tetrakisphosphate kinase activity
- inositol 5-diphosphate pentakisphosphate 5-kinase activity
- inositol hexakisphosphate 5-kinase activity
- inositol hexakisphosphate 3-kinase activity
- inositol hexakisphosphate 1-kinase activity