RBPMS2 Gene Summary [Human]
The protein encoded by this gene is a member of the RNA recognition motif (RRM)-containing protein family and is involved in the development and dedifferentiation of digestive smooth muscle cells. The encoded protein functions as a homodimer and indirectly inhibits the bone morphogenetic protein pathway. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | RBPMS2 |
| Official Name | RNA binding protein, mRNA processing factor 2 [Source:HGNC Symbol;Acc:HGNC:19098] |
| Ensembl ID | ENSG00000166831 |
| Bio databases IDs | |
| Aliases | RNA binding protein, mRNA processing factor 2 |
| Synonyms | 2400008B06Rik, RGD1561222, RNA binding protein, mRNA processing factor 2, RNA binding protein with multiple splicing 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RBPMS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- protein homodimerization
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal aortic aneurysm
- epithelial uterine cancer
- cervical cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
role in cell
- differentiation
- alternative splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RBPMS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell proliferation
- negative regulation of BMP signaling pathway
- regulation of alternative nuclear mRNA splicing, via spliceosome
- negative regulation of smooth muscle cell differentiation
- embryonic digestive tract morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- mRNA binding