Lasp1 Gene Summary [Mouse]
Enables actin filament binding activity. Predicted to be involved in monoatomic ion transport. Located in cytoplasm and focal adhesion. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and hemolymphoid system gland. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lasp1 |
| Official Name | LIM and SH3 protein 1 [Source:MGI Symbol;Acc:MGI:109656] |
| Ensembl ID | ENSMUSG00000038366 |
| Bio databases IDs | |
| Aliases | LIM and SH3 protein 1 |
| Synonyms | Def-4, LIM and SH3 protein 1, MLN 50, SH3P6, Tg(Col1a1-lacZ)1Ngma |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lasp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- ion transporter
- protein binding
- zDHHC ankyrin repeat binding domain
- transporter
- Src Homology 3 domain superfamily
- Nebulin repeat
Pathways
Biological processes and signaling networks where the Lasp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- diffuse systemic sclerosis
role in cell
- expression in
- proliferation
- adhesion
- formation
- migration
- invasion by
- phosphorylation in
- binding in
- invasion
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical actin cytoskeleton
- cytoskeleton
- postsynaptic region
- focal adhesions
- Nucleus
- cytosol
- cell membrane-lagging edges
- dendritic spines
- growth cone
- actin stress fibers
- pseudopodia
- filopodia
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lasp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- metal ion binding
- cadherin binding
- ion transmembrane transporter activity