Snx14 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity. Involved in postsynaptic modulation of chemical synaptic transmission. Is active in synapse. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 20. Orthologous to human SNX14 (sorting nexin 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snx14 |
| Official Name | sorting nexin 14 [Source:MGI Symbol;Acc:MGI:2155664] |
| Ensembl ID | ENSMUSG00000032422 |
| Bio databases IDs | |
| Aliases | sorting nexin 14 |
| Synonyms | B830022K16, C330035N22RIK, RGS-PX2, SCAR20, sorting nexin 14, YR-14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snx14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- binding protein
- PXA domain
- Sorting nexin C terminal
- Regulator of G protein signaling (RGS) domain superfamily
- The Phox Homology domain, a phosphoinositide binding module
- phosphatidylinositol binding
- PX domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- lysosome
- Endoplasmic Reticulum
- cytosol
- synapse
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snx14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- dendrite
- intracellular membrane-bounded organelle
- late endosome
- cytosol
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol binding
- phosphatidylinositol-3,5-bisphosphate binding