SNX14 Gene Summary [Human]
This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | SNX14 |
| Official Name | sorting nexin 14 [Source:HGNC Symbol;Acc:HGNC:14977] |
| Ensembl ID | ENSG00000135317 |
| Bio databases IDs | |
| Aliases | sorting nexin 14 |
| Synonyms | B830022K16, C330035N22RIK, RGS-PX2, SCAR20, sorting nexin 14, YR-14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNX14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- binding protein
- PXA domain
- Sorting nexin C terminal
- Regulator of G protein signaling (RGS) domain superfamily
- The Phox Homology domain, a phosphoinositide binding module
- phosphatidylinositol binding
- PX domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- lysosome
- Endoplasmic Reticulum
- cytosol
- synapse
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SNX14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- dendrite
- intracellular membrane-bounded organelle
- late endosome
- cytosol
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol binding
- phosphatidylinositol-3,5-bisphosphate binding