Stac Gene Summary [Mouse]
Enables transmembrane transporter binding activity. Involved in positive regulation of protein localization to plasma membrane and positive regulation of voltage-gated calcium channel activity. Acts upstream of or within cellular response to heat; muscle contraction; and regulation of voltage-gated calcium channel activity. Located in T-tubule and cytoplasmic side of plasma membrane. Is expressed in lens. Orthologous to human STAC (SH3 and cysteine rich domain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Stac |
| Official Name | src homology three (SH3) and cysteine rich domain [Source:MGI Symbol;Acc:MGI:1201400] |
| Ensembl ID | ENSMUSG00000032502 |
| Bio databases IDs | |
| Aliases | src homology three (SH3) and cysteine rich domain |
| Synonyms | SH3 and cysteine rich domain, src homology three (SH3) and cysteine rich domain, STAC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stac often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Unstructured on SH3 and cysteine-rich domain-containing protein 2
- protein kinase C conserved region 1 (C1 domain) superfamily
- ion channel binding
- protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic face of plasma membrane
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stac gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to heat
- skeletal muscle contraction
- signal transduction
- positive regulation of cation channel activity
Cellular Component
Where in the cell the gene product is active
- T-tubule
- cytosol
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- ion channel binding