STAC Gene Summary [Human]
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated calcium channel activity; and skeletal muscle contraction. Predicted to act upstream of or within cellular response to heat; muscle contraction; and regulation of voltage-gated calcium channel activity. Predicted to be located in T-tubule. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | STAC |
| Official Name | SH3 and cysteine rich domain [Source:HGNC Symbol;Acc:HGNC:11353] |
| Ensembl ID | ENSG00000144681 |
| Bio databases IDs | |
| Aliases | SH3 and cysteine rich domain |
| Synonyms | SH3 and cysteine rich domain, src homology three (SH3) and cysteine rich domain, STAC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STAC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Unstructured on SH3 and cysteine-rich domain-containing protein 2
- protein kinase C conserved region 1 (C1 domain) superfamily
- ion channel binding
- protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic face of plasma membrane
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STAC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to heat
- skeletal muscle contraction
- signal transduction
- positive regulation of cation channel activity
Cellular Component
Where in the cell the gene product is active
- T-tubule
- cytosol
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- ion channel binding