Pja1 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Acts upstream of or within protein catabolic process. Located in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; ear; genitourinary system; and liver. Orthologous to human PJA1 (praja ring finger ubiquitin ligase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pja1 |
| Official Name | praja ring finger ubiquitin ligase 1 [Source:MGI Symbol;Acc:MGI:1101765] |
| Ensembl ID | ENSMUSG00000034403 |
| Bio databases IDs | |
| Aliases | praja ring finger ubiquitin ligase 1 |
| Synonyms | Neurodap1, PRAJA, PRAJA1, praja ring finger ubiquitin ligase 1, RNF70 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pja1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pja1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding