Slc25a38 Gene Summary [Mouse]
Predicted to enable glycine transmembrane transporter activity. Predicted to be involved in erythrocyte differentiation and glycine import into mitochondrion. Located in mitochondrial inner membrane. Is expressed in cranial ganglion; dorsal root ganglion; liver lobe; and medulla oblongata basal plate. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 2. Orthologous to human SLC25A38 (solute carrier family 25 member 38). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a38 |
| Official Name | solute carrier family 25, member 38 [Source:MGI Symbol;Acc:MGI:2384782] |
| Ensembl ID | ENSMUSG00000032519 |
| Bio databases IDs | |
| Aliases | solute carrier family 25, member 38 |
| Synonyms | appoptosin, AV019094, LOC100048873, RGD1311914, SIDBA2, solute carrier family 25 member 38, solute carrier family 25, member 38 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc25a38 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine transporter
- Mitochondrial carrier protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometrial cancer
- pyridoxine-refractory sideroblastic anemia 2
- Alzheimer disease
- ischemic stroke
- infarction
- SLC25A38-related disorder
- diverticulitis
regulated by
- sirolimus
- beta-estradiol
- APP
- 2-amino-5-phosphonovaleric acid
- succinic acid
- L-glutamic acid
- apatinib
regulates
- reactive oxygen species
- CASP3
- heme
role in cell
- activation in
- cell death
- apoptosis
- differentiation
- synthesis in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc25a38 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte differentiation
- heme biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- glycine transmembrane transporter activity