Mfn2 Gene Summary [Mouse]
Predicted to enable several functions, including GTP binding activity; enzyme binding activity; and identical protein binding activity. Involved in mitochondrial fusion; positive regulation of cold-induced thermogenesis; and type 2 mitophagy. Acts upstream of or within blastocyst formation and camera-type eye morphogenesis. Located in microtubule cytoskeleton and mitochondrion. Is expressed in several structures, including early conceptus; eye; heart; oocyte; and tibialis anterior. Used to study Charcot-Marie-Tooth disease type 2A2A. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; Charcot-Marie-Tooth disease type 6; and multiple symmetric lipomatosis. Orthologous to human MFN2 (mitofusin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mfn2 |
| Official Name | mitofusin 2 [Source:MGI Symbol;Acc:MGI:2442230] |
| Ensembl ID | ENSMUSG00000029020 |
| Bio databases IDs | |
| Aliases | mitofusin 2 |
| Synonyms | CMT2A, CMT2A2, CMT2A2A, CMT2A2B, CPRP1, D630023P19Rik, Fzo, HMSN6A, HSG, LOC100911485, MARF, mitofusin 2, MSL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mfn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- ubiquitin protein ligase binding
- enzyme binding
- enzyme
- protein binding
- identical protein binding
- Dynamin family
- GTP binding
- fzo-like conserved region
- p21ras signature motif
- binding protein
- transmembrane domain
- GTP binding motif, P-loop
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Mfn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- peripheral neuropathy
- psoriasis
- chronic obstructive pulmonary disease
- sarcopenia
- breast cancer
- Charcot-Marie-Tooth disease axonal type 2A2
- Charcot-Marie-Tooth disease type 2
- autosomal recessive axonal Charcot-Marie-Tooth disease type 2A2B
- Charcot-Marie-Tooth disease type 2A
regulated by
- docosahexaenoic acid
- doxorubicin
- imatinib
- oligomycin A
- antimycin A
- forskolin
- Esat6
- Z-LLL-CHO
- JNK
- MARCHF5
role in cell
- function
- function in
- synthesis in
- expression in
- formation in
- production in
- cell death
- autophagy in
- phosphorylation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- pH resistant lipid raft fraction
- microtubule cytoskeleton
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial cristae
- mitochondrial matrix
- mitochondrial outer membrane
- neurites
- perikaryon
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mfn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to pre-autophagosomal structure
- mitochondrial fusion
- response to unfolded protein
- mitochondrial membrane organization
- protein targeting to mitochondrion
- camera-type eye morphogenesis
- negative regulation of Ras protein signal transduction
- apoptotic process
- negative regulation of smooth muscle cell proliferation
- blastocyst formation
- aerobic respiration
- mitochondrion localization
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- ubiquitin protein ligase binding
- GTPase activity