Cpne4 Gene Summary [Mouse]
Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion. Is active in glutamatergic synapse. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human CPNE4 (copine 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpne4 |
| Official Name | copine IV [Source:MGI Symbol;Acc:MGI:1921270] |
| Ensembl ID | ENSMUSG00000032564 |
| Bio databases IDs | |
| Aliases | copine IV |
| Synonyms | 3632411M23Rik, 4933406O10Rik, copine 4, copine IV, COPN4, CPN4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cpne4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Copine
- vWFA
- protein binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- epithelial cancer
- amyotrophic lateral sclerosis
- acute myeloid leukemia
- prostate cancer
- COVID-19
- drug allergy
- eosinophilic esophagitis
- motion sickness
regulates
- NFkB (complex)
- HAMP
role in cell
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- synaptic vesicles
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cpne4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to calcium ion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- calcium-dependent phospholipid binding