Ccdc22 Gene Summary [Mouse]
Predicted to enable cullin family protein binding activity. Predicted to be involved in several processes, including intracellular copper ion homeostasis; regulation of canonical NF-kappaB signal transduction; and vesicle-mediated transport to the plasma membrane. Predicted to act upstream of or within cholesterol homeostasis and regulation of plasma lipoprotein particle levels. Predicted to be located in centrosome. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 2. Orthologous to human CCDC22 (coiled-coil domain containing 22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccdc22 |
| Official Name | coiled-coil domain containing 22 [Source:MGI Symbol;Acc:MGI:1859608] |
| Ensembl ID | ENSMUSG00000031143 |
| Bio databases IDs | |
| Aliases | coiled-coil domain containing 22 |
| Synonyms | coiled-coil domain containing 22, CXorf37, DXImx40e, JM1, Ppp1r3f, RGD1560910, RTSC2, Sfc22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccdc22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain
- Coiled-coil domain-containing protein 22
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centriolar satellite
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccdc22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- cellular copper ion homeostasis
- cytoplasmic sequestering of NF-kappaB
- protein transport
- Golgi to plasma membrane transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- centrosome
- endosome
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding