Mon1a Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within establishment of localization in cell; intracellular iron ion homeostasis; and protein secretion. Predicted to be part of Mon1-Ccz1 complex. Orthologous to human MON1A (MON1 homolog A, secretory trafficking associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mon1a |
| Official Name | MON1 homolog A, secretory traffciking associated [Source:MGI Symbol;Acc:MGI:1920075] |
| Ensembl ID | ENSMUSG00000032583 |
| Bio databases IDs | |
| Aliases | MON1 homolog A, secretory traffciking associated |
| Synonyms | 2810468K17Rik, MON1 homolog A, secretory traffciking associated, MON1 homolog A, secretory trafficking associated, RGD1308823, SAND1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mon1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Third Longin domain of FUZ, MON1 and HPS1
- First Longin domain of FUZ, MON1 and HPS1
- guanyl-nucleotide exchange factor
- protein binding
- protein fuzzy and homologs
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mon1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- protein secretion
- protein targeting to vacuole
Cellular Component
Where in the cell the gene product is active
- cytosol
- Mon1-Ccz1 complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity