Rmc1 Gene Summary [Mouse]
Predicted to be involved in regulation of autophagy. Predicted to be located in lysosomal membrane. Predicted to be part of Mon1-Ccz1 complex. Predicted to be active in late endosome membrane. Is expressed in several structures, including adrenal gland; genitourinary system; liver; lung; and spleen. Orthologous to human RMC1 (regulator of MON1-CCZ1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rmc1 |
| Official Name | regulator of MON1-CCZ1 [Source:MGI Symbol;Acc:MGI:1916528] |
| Ensembl ID | ENSMUSG00000024410 |
| Bio databases IDs | |
| Aliases | regulator of MON1-CCZ1 |
| Synonyms | 2400010D15Rik, 3110002H16Rik, C18orf8, HsT2591, MIC1, regulator of MON1-CCZ1, RGD1311805, WDR98 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rmc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Colon cancer-associated protein Mic1-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- preeclampsia
- pancreatic cancer
- chronic pancreatitis
regulated by
- 5-fluorouracil
- 4-hydroxycinnamyl aldehyde
- 2-amino-5-phosphonovaleric acid
- Ribosome 80S
- FCGR1A
role in cell
- cell death
- capivasertib resistance
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rmc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- regulation of autophagy
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- Mon1-Ccz1 complex
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding