Tab1 Gene Summary [Mouse]
Enables kinase activator activity. Acts upstream of or within several processes, including circulatory system development; positive regulation of MAPK cascade; and transforming growth factor beta receptor signaling pathway. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and endoplasmic reticulum membrane. Is expressed in brain and genitourinary system. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tab1 |
| Official Name | TGF-beta activated kinase 1/MAP3K7 binding protein 1 [Source:MGI Symbol;Acc:MGI:1913763] |
| Ensembl ID | ENSMUSG00000022414 |
| Bio databases IDs | |
| Aliases | TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| Synonyms | 2310012M03Rik, 3'-Tab1, b2b449Clo, MAP3K7IP1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF Beta-Activated Kinase-Binding Protein 1, TGF-β activated kinase 1 (MAP3K7) binding protein 1, TGF-β activated kinase 1/MAP3K7 binding protein 1, TGF β-Activated Kinase-Binding Protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tab1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- Protein phosphatase 2C
- pseudophosphatase domain
- mitogen-activated protein kinase p38 binding
- enzyme
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- kinase
- protein kinase activator
- binding protein
- kinase activator
- PP2Cc
- TAK1 binding domain
Pathways
Biological processes and signaling networks where the Tab1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- BMP signaling pathway
- Cardiac Hypertrophy Signaling
- Glucocorticoid Receptor Signaling
- IL-1 Signaling
- IL-10 Signaling
- IL-6 Signaling
- iNOS Signaling
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
- SAPK/JNK Signaling
- TGF-β Signaling
- Toll-like Receptor Signaling
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- edema
- coronary artery disease
- venous thromboembolism
- hydrops fetalis
- ischemic stroke
- complete testicular feminization syndrome
- hypoplasia
- congenital heart disease
role in cell
- cell viability
- activation in
- interaction in
- proliferation
- migration
- expression in
- cell death
- invasion by
- function
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- endosomal membrane
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tab1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart morphogenesis
- in utero embryonic development
- aorta development
- protein dephosphorylation
- coronary vasculature development
- transforming growth factor beta receptor signaling pathway
- NIK/NF-kappaB cascade
- positive regulation of MAPK cascade
- positive regulation of protein serine/threonine kinase activity
- lung development
- cardiac septum development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- nuclear speck
- cytosol
- macromolecular complex
- endosome membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- mitogen-activated protein kinase p38 binding
- protein serine/threonine kinase activator activity
- binding, bridging