Apeh Gene Summary [Mouse]
Predicted to enable identical protein binding activity; omega peptidase activity; and serine-type endopeptidase activity. Predicted to be involved in amyloid-beta metabolic process and proteolysis. Predicted to be located in cytosol and nuclear membrane. Is expressed in dorsal root ganglion and liver lobe. Orthologous to human APEH (acylaminoacyl-peptide hydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apeh |
| Official Name | acylpeptide hydrolase [Source:MGI Symbol;Acc:MGI:88041] |
| Ensembl ID | ENSMUSG00000032590 |
| Bio databases IDs | |
| Aliases | acylpeptide hydrolase |
| Synonyms | AARE, ACPH, acylaminoacyl-peptide hydrolase, ACYLPEPTIDE HYDROLASE, Apeh14, Apeh17, APH, D3F15S2, D3S48E, DNF15S2, LOC255861, OPH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apeh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- BD-FAE
- alpha/beta hydrolase fold
- serine endopeptidase
- alpha/beta hydrolases
- Serine aminopeptidase, S33
- omega peptidase
- peptidase
- protein binding
- identical protein binding
- acylaminoacyl-peptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apeh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- translational termination
- proteolysis
- beta-amyloid metabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- extracellular vesicular exosome
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- omega peptidase activity
- serine-type endopeptidase activity