Arid1a Gene Summary [Mouse]
Enables ATP-dependent chromatin remodeler activity. Contributes to nucleosome binding activity. Acts upstream of or within several processes, including circulatory system development; embryo implantation; and embryonic morphogenesis. Located in chromatin. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study Coffin-Siris syndrome. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 2; breast cancer; carcinoma (multiple); gastrointestinal system cancer (multiple); and neuroblastoma. Orthologous to human ARID1A (AT-rich interaction domain 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arid1a |
| Official Name | AT rich interactive domain 1A (SWI-like) [Source:MGI Symbol;Acc:MGI:1935147] |
| Ensembl ID | ENSMUSG00000007880 |
| Bio databases IDs | |
| Aliases | AT rich interactive domain 1A (SWI-like) |
| Synonyms | 1110030E03Rik, AT-rich interaction domain 1A, B120, BAF250, BAF250A, BM029, C1orf4, CSS2, ELD, hELD, hOSA1, HSP16.2, MRD14, OSA1, P270, SMARCF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arid1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ligand-dependent nuclear receptor interactor
- LXXLL motif
- transcription co-activator
- binding protein
- chromatin binding
- protein binding
- DNA dependent ATPase
- ARID/BRIGHT DNA binding domain
- DNA binding
- SWI/SNF-like complex subunit BAF250/Osa
- ARID/BRIGHT DNA binding domain family
Pathways
Biological processes and signaling networks where the Arid1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- autosomal dominant mental retardation type 14
- ARID1A-related disorder
- bladder cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- metastasis
- non-Hodgkin lymphoma
- non-Hodgkin disease
role in cell
- accumulation in
- quantity
- expression in
- apoptosis
- number
- activation in
- phosphorylation in
- growth
- binding in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arid1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glucocorticoid receptor signaling pathway
- regulation of mitotic metaphase/anaphase transition
- positive regulation of gene expression, epigenetic
- nervous system development
- positive regulation of myoblast differentiation
- positive regulation of cell differentiation
- regulation of nucleotide-excision repair
- nucleosome disassembly
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- positive regulation of T cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- androgen receptor signaling pathway
- intracellular estrogen receptor signaling pathway
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- nucleus
- SWI/SNF complex
- npBAF complex
- brahma complex
- nBAF complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ligand-dependent nuclear receptor binding
- protein binding
- transcription coactivator activity
- nucleosome binding