Klhdc8b Gene Summary [Mouse]
Predicted to be involved in mitotic cytokinetic process; mitotic nuclear division; and nuclear chromosome segregation. Predicted to be located in cytosol. Predicted to be active in cellularization cleavage furrow; intercellular bridge; and midbody. Is expressed in heart. Human ortholog(s) of this gene implicated in Hodgkin's lymphoma. Orthologous to human KLHDC8B (kelch domain containing 8B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhdc8b |
| Official Name | kelch domain containing 8B [Source:MGI Symbol;Acc:MGI:1925517] |
| Ensembl ID | ENSMUSG00000032609 |
| Bio databases IDs | |
| Aliases | kelch domain containing 8B |
| Synonyms | 4931406O17Rik, CHL, kelch domain containing 8B, LOC100364166 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhdc8b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- major depression
- insomnia
- classic Hodgkin disease
- aldosterone producing adrenocortical adenoma
- adenoma formation
- depressive disorder
- mood disorder
- Hodgkin lymphoma
- Hodgkin disease
role in cell
- multinucleation
- segregation
- amplification
- amplification in
- abscission
- segregation in
- aneuploidy
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- midbody
- cytoplasmic bridges
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhdc8b gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- cytoplasm
- cytosol
- midbody