Rybp Gene Summary [Mouse]
Enables DNA binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Is expressed in several structures, including central nervous system; early embryo; extraembryonic component; genitourinary system; and hemolymphoid system gland. Orthologous to human RYBP (RING1 and YY1 binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rybp |
| Official Name | RING1 and YY1 binding protein [Source:MGI Symbol;Acc:MGI:1929059] |
| Ensembl ID | ENSMUSG00000072872 |
| Bio databases IDs | |
| Aliases | RING1 and YY1 binding protein |
| Synonyms | 2410018J24Rik, AAP1, APAP-1, DEDAF, LOC120102351, RING1 and YY1 binding protein, YEAF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rybp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Yaf2/RYBP C-terminal binding motif
- Zn-finger in Ran binding protein and others
- nucleic acid binding
- transcription co-repressor
- protein binding
- zinc finger domain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplastic cell transformation
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
- squamous cell lung cancer
- mucopolysaccharidosis type IVB
- covid-19 death
- mucopolysaccharidosis, MPS-IV-A
role in cell
- proliferation
- phosphorylation in
- apoptosis
- expression in
- activation in
- remodeling
- formation
- upregulation in
- migration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rybp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- apoptotic process
- positive regulation of apoptotic process
- regulation of transcription, DNA-dependent
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- PcG protein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- DNA binding
- transcription cofactor activity
- protein binding
- metal ion binding
- transcription corepressor activity