Crebl2 Gene Summary [Mouse]
Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including positive regulation of D-glucose import; positive regulation of metabolic process; and protein stabilization. Located in nucleus. Orthologous to human CREBL2 (cAMP responsive element binding protein like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crebl2 |
| Official Name | cAMP responsive element binding protein-like 2 [Source:MGI Symbol;Acc:MGI:1889385] |
| Ensembl ID | ENSMUSG00000032652 |
| Bio databases IDs | |
| Aliases | cAMP responsive element binding protein-like 2 |
| Synonyms | AI046348, B230205M03, cAMP responsive element binding protein-like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crebl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Basic region leucine zipper
- protein binding
- bZIP
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- major depression
- Alzheimer disease
- squamous-cell carcinoma
- systemic lupus erythematosus
- squamous cell cancer
regulates
- D-glucose
- lipid
- peptide
role in cell
- apoptosis
- differentiation
- necroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crebl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- signal transduction
- cell differentiation
- positive regulation of glucose import
- positive regulation of fat cell differentiation
- regulation of transcription, DNA-dependent
- protein stabilization
- regulation of transcription from RNA polymerase II promoter
- positive regulation of lipid biosynthetic process
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity