Ube2i Gene Summary [Mouse]
Enables HLH domain binding activity and SUMO conjugating enzyme activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nuclear export; and protein sumoylation. Acts upstream of or within positive regulation of canonical NF-kappaB signal transduction. Located in nuclear body. Part of SUMO ligase complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including early embryo; forebrain; forelimb bud; limb; and oocyte. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2i |
| Official Name | ubiquitin-conjugating enzyme E2I [Source:MGI Symbol;Acc:MGI:107365] |
| Ensembl ID | ENSMUSG00000015120 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2I |
| Synonyms | 5830467E05Rik, C358B7.1, F830028O17RIK, P18, SUMO E2, UBC9, UbcE2A, Ubce2i, Ubce9, ubiquitin-conjugating enzyme E2I |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2i often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- SUMO transferase activity
- SUMO conjugating enzyme
- catalytic domain
- ubiquitin-protein transferase activity
- enzyme binding
- transcription factor binding
- protein domain specific binding
- UBCc_UEV
- enzyme
- protein binding
- ionotropic glutamate receptor binding
Pathways
Biological processes and signaling networks where the Ube2i gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- adenoma formation
- Hutchinson-Gilford progeria syndrome
- psoriasis
- refractive error
- atopic dermatitis
- cortisol-producing adrenal cortical adenoma
- non-small cell lung cancer
- mechanical hyperalgesia
- dextran sodium sulfate-induced colitis
role in cell
- migration
- phosphorylation in
- expression in
- proliferation
- cell death
- apoptosis
- activation in
- cell viability
- growth
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- plasma membrane fraction
- nuclear fraction
- membrane fraction
- nuclear filaments
- glutaminergic synapse
- fibrillar center
- Cytoplasm
- intracellular membranes
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- trans Golgi network
- nuclear foci
- nuclear pores
- nucleoplasm
- nuclear bodies
- nuclear envelope
- synapse
- PML nuclear bodies
- synaptonemal complexes
- dendrites
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2i gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cell division
- protein modification process
- mitotic nuclear envelope reassembly
- nuclear export
- negative regulation of transcription, DNA-dependent
- protein sumoylation
- chromosome segregation
- positive regulation of cell migration
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- perinuclear region of cytoplasm
- PML body
- cytoplasm
- cytosol
- synaptonemal complex
- nucleoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- ATP binding
- transcription cofactor binding
- RNA binding
- protein binding
- small protein activating enzyme binding
- RING-like zinc finger domain binding
- transcription factor binding
- SUMO ligase activity
- enzyme binding