Pknox2 Gene Summary [Mouse]
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; actin filament binding activity; and actin monomer binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in cytoplasm; cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PKNOX2 (PBX/knotted 1 homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pknox2 |
| Official Name | Pbx/knotted 1 homeobox 2 [Source:MGI Symbol;Acc:MGI:2445415] |
| Ensembl ID | ENSMUSG00000035934 |
| Bio databases IDs | |
| Aliases | Pbx/knotted 1 homeobox 2 |
| Synonyms | D230005H23Rik, LOC100364346, PBX/knotted 1 homeobox 2, PREP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pknox2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- actin monomer binding
- protein binding
- sequence-specific DNA binding
- N-terminal of Homeobox Meis and PKNOX1
- homeodomain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- age-related macular degeneration
- colorectal cancer
- epithelial cancer
- Alzheimer disease
- COVID-19
- alcoholism
- prostate cancer
- prostatic carcinoma
role in cell
- expression in
- invasion by
- migration
- apoptosis
- cell cycle progression
- proliferation
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- Cytoplasm
- actin cytoskeleton
- microtubules
- cytoplasmic bridges
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pknox2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- microtubule cytoskeleton
- cytoplasm
- actin cytoskeleton
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- actin monomer binding