Arhgef17 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be active in cytoplasm. Orthologous to human ARHGEF17 (Rho guanine nucleotide exchange factor 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef17 |
| Official Name | Rho guanine nucleotide exchange factor (GEF) 17 [Source:MGI Symbol;Acc:MGI:2673002] |
| Ensembl ID | ENSMUSG00000032875 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor (GEF) 17 |
| Synonyms | 8030463K16, AI428794, AW558066, mKIAA0337, P164RHOGEF, RHOGEF17, Rho guanine nucleotide exchange factor 17, TEM4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgef17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- central domain
- protein binding
- Dbl homology domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the Arhgef17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- chronic obstructive pulmonary disease
- metastasis
- advanced cancer
- organismal death
- early missed abortion
role in cell
- activation in
- motility
- migration
- formation
- invasion by
- organization
- spindle checkpoint in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgef17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity