Ap4b1 Gene Summary [Mouse]
Predicted to enable clathrin binding activity. Involved in protein localization to somatodendritic compartment and protein targeting. Located in trans-Golgi network. Is expressed in cerebral cortex ventricular layer and cortical plate. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 47. Orthologous to human AP4B1 (adaptor related protein complex 4 subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap4b1 |
| Official Name | adaptor-related protein complex AP-4, beta 1 [Source:MGI Symbol;Acc:MGI:1337130] |
| Ensembl ID | ENSMUSG00000032952 |
| Bio databases IDs | |
| Aliases | adaptor-related protein complex AP-4, beta 1 |
| Synonyms | 1810038H16RIK, adaptor related protein complex 4 subunit beta 1, adaptor related protein complex 4 subunit β 1, adaptor-related protein complex AP-4, beta 1, adaptor-related protein complex AP-4, β 1, Ap4b4, Ap4 β 4, BETA-4, CPSQ5, SPG47, β-4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ap4b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- non-SMC mitotic condensation complex subunit 1
- protein binding
- Adaptin N terminal region
- HEAT repeats
- Beta2-adaptin appendage, C-terminal sub-domain
Pathways
Biological processes and signaling networks where the Ap4b1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- GABA
disease
- epithelial cancer
- spastic paraplegia
- autosomal recessive spastic paraplegia type 47
- epithelial basal cell carcinoma
- hereditary disorder
- hereditary spastic paraplegia
- breast carcinoma
- AP4-deficiency syndrome
- skin neoplasm
- skin neoplasia
role in cell
- activation in
- accumulation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- endosomes
- cytosol
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ap4b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- vesicle-mediated transport
- protein localization
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- endosome lumen
- cytosol
- clathrin adaptor complex
- AP-4 adaptor complex
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- clathrin binding