Ap4m1 Gene Summary [Mouse]
Predicted to enable protein domain specific binding activity. Involved in protein targeting. Predicted to be located in early endosome. Predicted to be part of AP-4 adaptor complex. Predicted to be active in cytoplasmic vesicle and trans-Golgi network. Is expressed in brain. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human AP4M1 (adaptor related protein complex 4 subunit mu 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap4m1 |
| Official Name | adaptor-related protein complex AP-4, mu 1 [Source:MGI Symbol;Acc:MGI:1337063] |
| Ensembl ID | ENSMUSG00000019518 |
| Bio databases IDs | |
| Aliases | adaptor-related protein complex AP-4, mu 1 |
| Synonyms | 4930443L05Rik, adaptor related protein complex 4 subunit mu 1, adaptor-related protein complex AP-4, mu 1, Ap4m4, CPSQ3, MU-4, MU-ARP2, SPG50 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ap4m1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein carrier
- Clathrin adaptor complex small chain
- AP_MHD_Cterm
- protein domain specific binding
- Adaptor complexes medium subunit family
- protein binding
- Longin-like domains
Pathways
Biological processes and signaling networks where the Ap4m1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mental retardation
- Alzheimer disease
- autosomal recessive spastic paraplegia type 50
- spastic paraplegia
- hereditary disorder
- AP4-deficiency syndrome
- hereditary spastic paraplegia
- autosomal recessive nonsyndromic mental retardation
role in cell
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- endosomes
- trans Golgi network
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ap4m1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transmembrane transport
- autophagic vacuole assembly
- protein targeting
- vesicle-mediated transport
- protein localization
- post-Golgi vesicle-mediated transport
- protein targeting to lysosome
- Golgi to lysosome transport
- intracellular protein transport
- Golgi to endosome transport
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- early endosome
- extracellular vesicular exosome
- endosome lumen
- cytosol
- cytoplasmic vesicle
- clathrin adaptor complex
- AP-4 adaptor complex
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- protein transmembrane transporter activity