Atg9a Gene Summary [Mouse]
Predicted to enable phospholipid scramblase activity. Involved in autophagy; bone morphogenesis; and programmed necrotic cell death. Acts upstream of or within several processes, including autophagosome assembly; negative regulation of cytokine production; and protein localization to Golgi apparatus. Located in Golgi membrane; autophagosome; and endoplasmic reticulum membrane. Is active in synaptic membrane. Is expressed in brain; cochlea; heart; liver; and lung. Orthologous to human ATG9A (autophagy related 9A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg9a |
| Official Name | autophagy related 9A [Source:MGI Symbol;Acc:MGI:2138446] |
| Ensembl ID | ENSMUSG00000033124 |
| Bio databases IDs | |
| Aliases | autophagy related 9A |
| Synonyms | APG9L1, Atg9, Atg9l1, autophagy related 9A, mATG9, MGD3208, RGD1310450 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atg9a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein ATG9
- phospholipid scramblase
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Atg9a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- synaptic membrane
- Golgi membrane
- trans Golgi network
- endosomal membrane
- synaptic vesicles
- autophagic vacuoles
- recycling endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atg9a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- piecemeal microautophagy of nucleus
- programmed necrotic cell death
- protein localization to pre-autophagosomal structure
- bone morphogenesis
- phospholipid scrambling
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- late endosome
- Golgi apparatus
- Golgi membrane
- autophagic vacuole
- autophagic vacuole membrane
- endoplasmic reticulum membrane
- late endosome membrane
- trans-Golgi network
- endosome
- mitochondrial membrane
- intracellular membrane-bounded organelle
- membrane
- mitochondrion
- recycling endosome
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phospholipid scramblase activity