Scaf11 Gene Summary [Mouse]
Predicted to be involved in spliceosomal complex assembly. Predicted to be located in nuclear body and nucleolus. Is expressed in cerebral cortex ventricular layer; diencephalon lateral wall ventricular layer; heart ventricle; midbrain ventricular layer; and telencephalon ventricular layer. Orthologous to human SCAF11 (SR-related CTD associated factor 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scaf11 |
| Official Name | SR-related CTD-associated factor 11 [Source:MGI Symbol;Acc:MGI:1919443] |
| Ensembl ID | ENSMUSG00000033228 |
| Bio databases IDs | |
| Aliases | SR-related CTD-associated factor 11 |
| Synonyms | 1110061H03Rik, 2610510E10Rik, CASP11, LOC681974, mKIAA3013, SFRS2IP, SIP1, SR-related CTD-associated factor 11, SRRP129, SRSF2IP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scaf11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- zinc finger of C3HC4-type, RING
- Ring finger
- Ring finger domain
- protein binding
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- osteoarthritis
- rheumatoid arthritis
- experimental peritonitis
- periodontitis
regulated by
- tretinoin
- mir-30 (includes others)
- Jurkat E6.1 cells
- FGFR1
- dexamethasone
- Immunoglobulin
- CD24
- mir-122 (includes others)
- progesterone
- CST5
regulates
- IL1B
- HBB
role in cell
- growth
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scaf11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- RNA splicing
- mRNA processing
- spliceosomal complex assembly
Cellular Component
Where in the cell the gene product is active
- nuclear body
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding