Bcor Gene Summary [Mouse]
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription corepressor activity. Acts upstream of or within blastocyst hatching and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; eye; gonad; lung; and nervous system. Used to study syndromic microphthalmia 2. Human ortholog(s) of this gene implicated in dental caries; eye disease (multiple); and gastrointestinal system cancer (multiple). Orthologous to human BCOR (BCL6 corepressor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcor |
| Official Name | BCL6 interacting corepressor [Source:MGI Symbol;Acc:MGI:1918708] |
| Ensembl ID | ENSMUSG00000040363 |
| Bio databases IDs | |
| Aliases | BCL6 interacting corepressor |
| Synonyms | 2900008C10Rik, 5830466J11Rik, 8430401K06Rik, ANOP2, BCL6 co-repressor, BCL6 interacting corepressor, BcorR, D930024N20Rik, FLJ20285, MAA2, MCOPS2, mKIAA1575, RGD1562735 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcor often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- nucleic acid binding
- transcription co-repressor
- heat shock protein binding
- Ankyrin repeats (3 copies)
- transcription factor binding
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- Ankyrin repeat
- double-stranded DNA binding
- PCGF Ub-like fold discriminator and related domains
- ubiquitin-protein transferase activity
- BCL-6 co-repressor, non-ankyrin-repeat region
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- skin cancer
- glioma
- sarcoma
- syndromic microphthalmia 2
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- myelodysplastic syndrome
role in cell
- apoptosis
- expression in
- proliferation
- formation
- differentiation
- remodeling
- mono-ubiquitination in
- upregulation in
- repopulation capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcor gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- negative regulation of bone mineralization
- chromatin remodeling
- negative regulation of tooth mineralization
- negative regulation of transcription, DNA-dependent
- specification of axis polarity
- palate development
- blastocyst hatching
- odontogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- heat shock protein binding
- protein binding
- histone deacetylase binding
- transcription corepressor activity
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding