Magea4 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor binding activity; histone deacetylase binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; gonad; heart; and liver. Orthologous to several human genes including MAGEA10 (MAGE family member A10) and MAGEA8 (MAGE family member A8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Magea4 |
| Official Name | MAGE family member A4 [Source:MGI Symbol;Acc:MGI:1333839] |
| Ensembl ID | ENSMUSG00000033343 |
| Bio databases IDs | |
| Aliases | MAGE family member A4 |
| Synonyms | CT1.4, MAGE4, MAGE-41, MAGE4A, MAGE4B, MAGE family member A4, MAGE-X2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Magea4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Melanoma associated antigen family N terminal
- MAGE homology domain
- transcription factor binding
- histone deacetylase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- neoplasia
- soft tissue sarcoma cancer
- ovarian cancer
- esophageal adenocarcinoma
- esophageal carcinoma formation
- synovial sarcoma
- neuroblastoma
- neuroblastoma formation
- MYCN amplification negative neuroblastoma
regulated by
- doxorubicin
- decitabine
- lactacystin
- N-carbobenzyloxy-leucine-leucine-norvalinal
- zVAD-FMK
- PRKAA1
- entinostat
- Z-LLL-CHO
- PLX 4720
- NLRP7
role in cell
- apoptosis
- growth
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Magea4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of apoptotic process
- positive regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding