MAGEA4 Gene Summary [Human]
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | MAGEA4 |
| Official Name | MAGE family member A4 [Source:HGNC Symbol;Acc:HGNC:6802] |
| Ensembl ID | ENSG00000147381 |
| Bio databases IDs | |
| Aliases | MAGE family member A4, melanoma-associated antigen 4, cancer/testis antigen family 1, member 4 |
| Synonyms | CT1.4, MAGE4, MAGE-41, MAGE4A, MAGE4B, MAGE family member A4, MAGE-X2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAGEA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Melanoma associated antigen family N terminal
- MAGE homology domain
- transcription factor binding
- histone deacetylase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- neoplasia
- soft tissue sarcoma cancer
- ovarian cancer
- esophageal adenocarcinoma
- esophageal carcinoma formation
- synovial sarcoma
- neuroblastoma
- neuroblastoma formation
- MYCN amplification negative neuroblastoma
role in cell
- apoptosis
- growth
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAGEA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of apoptotic process
- positive regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding