Uvssa Gene Summary [Mouse]
Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in protein ubiquitination; response to UV; and transcription-coupled nucleotide-excision repair. Predicted to be located in nucleoplasm. Predicted to be active in chromosome. Human ortholog(s) of this gene implicated in UV-sensitive syndrome. Orthologous to human UVSSA (UV stimulated scaffold protein A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Uvssa |
| Official Name | UV stimulated scaffold protein A [Source:MGI Symbol;Acc:MGI:1918351] |
| Ensembl ID | ENSMUSG00000037355 |
| Bio databases IDs | |
| Aliases | UV stimulated scaffold protein A |
| Synonyms | 4933407H18Rik, D330017J19RIK, KIAA1530, LOC100133766, LOC100912062, mKIAA1530, RGD1306371, UVSS3, UV-stimulated scaffold protein A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uvssa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme inhibitor activity
- protein binding activity, bridging
- Uncharacterized conserved protein (DUF2043)
- enzyme binding
- central domain
- protein binding
Pathways
Biological processes and signaling networks where the Uvssa gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sunburn
- UV-sensitive syndrome type 3
- human papilloma virus infection
regulated by
role in cell
- cell viability
- cell death
- phosphorylation in
- accumulation in
- apoptosis
- activation in
- cisplatin sensitivity
- synthesis in
- interaction in
- UV light sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uvssa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription-coupled nucleotide-excision repair
- response to UV
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core binding