Tmem35a Gene Summary [Mouse]
Enables acetylcholine receptor regulator activity. Involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Located in endoplasmic reticulum. Is expressed in adrenal gland; maturing glomerular tuft; nervous system; neural retina; and testis. Orthologous to human TMEM35A (transmembrane protein 35A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem35a |
| Official Name | transmembrane protein 35A [Source:MGI Symbol;Acc:MGI:1914814] |
| Ensembl ID | ENSMUSG00000033578 |
| Bio databases IDs | |
| Aliases | transmembrane protein 35A |
| Synonyms | 9030603L14Rik, NACHO, PMP52, RSEP4, TMEM35, transmembrane protein 35A, TUF-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem35a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- acetylcholine receptor regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem35a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization at cell surface
- chaperone-mediated protein complex assembly
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- peroxisomal membrane
- cytoplasmic vesicle
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetylcholine receptor regulator activity